Mark Segal, M.D.

Mark S Segal, M.D., Ph.D.

(352) 265-4845

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Publications

Management of Cardiovascular Disease in Kidney Disease Study: Rationale and Design.
American journal of nephrology
2021

Circulating endothelial cells as predictor of long-term mortality and adverse cardiovascular outcomes in hemodialysis patients.
Seminars in dialysis
2021

Association of early initiation of dialysis with all-cause and cardiovascular mortality: A propensity score weighted analysis of the United States Renal Data System.
Hemodialysis international. International Symposium on Home Hemodialysis
2021

Association of Intensive vs Standard Blood Pressure Control With Magnetic Resonance Imaging Biomarkers of Alzheimer Disease: Secondary Analysis of the SPRINT MIND Randomized Trial.
JAMA neurology
2021

Advancing Nephrology: Division Leaders Advise ASN.
Clinical journal of the American Society of Nephrology : CJASN
2021

Utilization of CMS pre-ESRD Kidney Disease Education services and its associations with the home dialysis therapies.
Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis
2020

Tubular Biomarkers and Chronic Kidney Disease Progression in SPRINT Participants.
American journal of nephrology
2020

Roxadustat for Anemia in Patients with Chronic Kidney Disease.
The New England journal of medicine
2020

Maternal endothelial function, circulating endothelial cells, and endothelial progenitor cells in pregnancies conceived with or without in vitro fertilization.
American journal of physiology. Regulatory, integrative and comparative physiology
2020

Graft-versus-host disease of the kidney.
Hematology/oncology and stem cell therapy
2020

Engineering magnetic nanoparticles and their integration with microfluidics for cell isolation.
Journal of colloid and interface science
2020

Clinical Trajectories of Acute Kidney Injury in Surgical Sepsis: A Prospective Observational Study.
Annals of surgery
2020

A Word of Caution in the Use of Hydroxychloroquine in the Elderly COVID-19 Population.
Asia-Pacific journal of ophthalmology (Philadelphia, Pa.)
2020

The utility of trough mycophenolic acid levels for the management of lupus nephritis.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
2019

Serum Sodium and Pulse Pressure in SPRINT.
American journal of hypertension
2019

Potential influence of the corpus luteum on circulating reproductive and volume regulatory hormones, angiogenic and immunoregulatory factors in pregnant women.
American journal of physiology. Endocrinology and metabolism
2019

Opioid Safety and Concomitant Benzodiazepine Use in End-Stage Renal Disease Patients.
Pain research & management
2019

Myeloid-derived suppressor cell function and epigenetic expression evolves over time after surgical sepsis.
Critical care (London, England)
2019

Maternal Cardiovascular Dysregulation During Early Pregnancy After In Vitro Fertilization Cycles in the Absence of a Corpus Luteum.
Hypertension (Dallas, Tex. : 1979)
2019

Integrating Point-of-Care Ultrasonography Into Nephrology Fellowship Training: A Model Curriculum.
American journal of kidney diseases : the official journal of the National Kidney Foundation
2019

Increased Preeclampsia Risk and Reduced Aortic Compliance With In Vitro Fertilization Cycles in the Absence of a Corpus Luteum.
Hypertension (Dallas, Tex. : 1979)
2019

Antihypertensive therapy prescribing patterns and correlates of blood pressure control among hypertensive patients with chronic kidney disease.
Journal of clinical hypertension (Greenwich, Conn.)
2019

Wave reflections and global arterial compliance during normal human pregnancy.
Physiological reports
2018

Pulse pressure, arterial stiffening, and the efficacy of renin-angiotensin system inhibitor combinations.
Journal of human hypertension
2018

Persistent inflammation, immunosuppression, and catabolism and the development of chronic critical illness after surgery.
Surgery
2018

Not all that is red is blood: a curious case of chromaturia.
Clinical case reports
2018

Gender, blood pressure, and cardiovascular and renal outcomes in adults with hypertension from the Systolic Blood Pressure Intervention Trial.
Journal of hypertension
2018

Development of a personalized diagnostic model for kidney stone disease tailored to acute care by integrating large clinical, demographics and laboratory data: the diagnostic acute care algorithm - kidney stones (DACA-KS).
BMC medical informatics and decision making
2018

Computational design and experimental characterization of a novel β-common receptor inhibitory peptide.
Peptides
2018

Chronic Critical Illness and the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome.
Frontiers in immunology
2018

Benchmarking clinical outcomes and the immunocatabolic phenotype of chronic critical illness after sepsis in surgical intensive care unit patients.
The journal of trauma and acute care surgery
2018

Activation of the β-common receptor by erythropoietin impairs acetylcholine-mediated vasodilation in mouse mesenteric arterioles.
Physiological reports
2018

Using Organizational Philosophy to Create a Self-Sustaining Compensation Plan Without Harming Academic Missions.
Academic medicine : journal of the Association of American Medical Colleges
2017

Tubulointerstitial Nephritis in Sjögren Syndrome Treated With Mycophenolate Mofetil.
Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases
2017

Sepsis and Critical Illness Research Center investigators: protocols and standard operating procedures for a prospective cohort study of sepsis in critically ill surgical patients.
BMJ open
2017

Conditional Deletion of Bmal1 Accentuates Microvascular and Macrovascular Injury
The American Journal Of Pathology
2017

Comparison of multiple non-invasive methods of measuring cardiac output during pregnancy reveals marked heterogeneity in the magnitude of cardiac output change between women.
Physiological reports
2017

Case Report of Spontaneous Remission of Biopsy-Proven Idiopathic Immune Complex-Mediated Membranoproliferative Glomerulonephritis.
Case reports in nephrology and dialysis
2017

Nebivolol Effects on Nitric Oxide Levels, Blood Pressure, and Renal Function in Kidney Transplant Patients.
Journal of clinical hypertension (Greenwich, Conn.)
2016

Effects of Long-Term Type I Interferon on the Arterial Wall and Smooth Muscle Progenitor Cells Differentiation.
Arteriosclerosis, thrombosis, and vascular biology
2016

Acute and Chronic Kidney Disease and Cardiovascular Mortality After Major Surgery.
Annals of surgery
2016

A case of isolated renal involvement of polyarteritis nodosa successfully treated with steroid monotherapy.
BMJ case reports
2016

A Novel Mechanism for Generating the Interferon Signature in Lupus: Opsonization of Dead Cells by Complement and IgM.
Arthritis & rheumatology (Hoboken, N.J.)
2016

The effect of the addition of allopurinol on blood pressure control in African Americans treated with a thiazide-like diuretic.
Journal of the American Society of Hypertension : JASH
2015

Renal function and coronary microvascular dysfunction in women with symptoms/signs of ischemia.
PloS one
2015

Mild renal dysfunction and long-term adverse outcomes in women with chest pain: results from the National Heart, Lung, and Blood Institute-sponsored Women's Ischemia Syndrome Evaluation (WISE).
American heart journal
2015

Impact of Hydroxychloroquine on Atherosclerosis and Vascular Stiffness in the Presence of Chronic Kidney Disease.
PloS one
2015

Higher levels of adiponectin in vascular endothelial cells are associated with greater brachial artery flow-mediated dilation in older adults.
Experimental gerontology
2015

Heart failure and chronic kidney disease: should we use spironolactone?
The American journal of the medical sciences
2015

Fiber supplementation lowers plasma p-cresol in chronic kidney disease patients.
Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation
2015

Early Angiogenic Balance and Adverse Long-Term Outcomes in Sepsis
Shock
2015

DNA Aptamer Assembly as a Vascular Endothelial Growth Factor Receptor Agonist.
Nucleic acid therapeutics
2015

Cost and Mortality Associated With Postoperative Acute Kidney Injury.
Annals of surgery
2015

Vasoreparative dysfunction of CD34+ cells in diabetic individuals involves hypoxic desensitization and impaired autocrine/paracrine mechanisms.
PloS one
2014

Uric acid inhibition of dipeptidyl peptidase IV in vitro is dependent on the intracellular formation of triuret.
Experimental cell research
2014

Monocyte activation by interferon α is associated with failure to achieve a sustained virologic response after treatment for hepatitis C virus infection.
The Journal of infectious diseases
2014

Evidence for Impaired Maternal Circulatory Adaptations in Pregnancies Conceived Using Donor Eggs
Reproductive Sciences
2014

End-stage renal disease in African Americans with lupus nephritis is associated with APOL1.
Arthritis & rheumatology (Hoboken, N.J.)
2014

The role of uric acid in the pathogenesis of human cardiovascular disease.
Heart (British Cardiac Society)
2013

Racial and socioeconomic disparities in the allocation of expanded criteria donor kidneys.
Clinical journal of the American Society of Nephrology : CJASN
2013

Number and function of bone-marrow derived angiogenic cells and coronary flow reserve in women without obstructive coronary artery disease: a substudy of the NHLBI-sponsored Women's Ischemia Syndrome Evaluation (WISE).
PloS one
2013

National surgical quality improvement program underestimates the risk associated with mild and moderate postoperative acute kidney injury.
Critical care medicine
2013

Mineralocorticoid receptors modulate vascular endothelial function in human obesity.
Clinical science (London, England : 1979)
2013

Mild Renal Insufficiency Predicts Mortality and Adverse Events in Women With Cardiac Ischemia, Independent of the Underlying Obstructive Coronary Artery Disease
Circulation
2013

Mild Renal Insufficiency Is An Independent Predictor of Coronary Microvascular Dysfunction Among Women With Symptoms/Signs of Ischemia: a Report From the Women's Ischemia Syndrome Evaluation (Wise)
Circulation
2013

Lupus nephritis and end-stage kidney disease.
The American journal of the medical sciences
2013

Long-term type 1 diabetes influences haematopoietic stem cells by reducing vascular repair potential and increasing inflammatory monocyte generation in a murine model.
Diabetologia
2013

Long-Term Administration of Type-I Interferon Leads To Premature Atherosclerosis
Circulation
2013

Foods with added fiber lower serum creatinine levels in patients with chronic kidney disease.
Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation
2013

Evaluation of stability and sensitivity of cell fluorescent labels when used for cell migration.
Journal of fluorescence
2013

Derivation of multivariate syndromic outcome metrics for consistent testing across multiple models of cervical spinal cord injury in rats.
PloS one
2013

13C NMR metabolomic evaluation of immediate and delayed mild hypothermia in cerebrocortical slices after oxygen-glucose deprivation.
Anesthesiology
2013

Relaxin increases human endothelial progenitor cell NO and migration and vasculogenesis in mice.
Blood
2012

Evaluation of Norepinephrine Transporter Expression and Metaiodobenzylguanidine Avidity in Neuroblastoma: A Report from the Children's Oncology Group.
International journal of molecular imaging
2012

Effects of high-fructose corn syrup and sucrose on the pharmacokinetics of fructose and acute metabolic and hemodynamic responses in healthy subjects.
Metabolism: clinical and experimental
2012

Effect of Postoperative Acute Kidney Injury On Hospital Cost
Critical Care Medicine
2012

Creatinine Clearance Predicts Poor Outcome in Emergency Department Presentation of Pediatric Sepsis
Critical Care Medicine
2012

Apolipoprotein L1 Risk Variants Underlie Racial Disparities in Lupus Nephritis-Induced End-Stage Renal Disease
Arthritis and Rheumatism
2012

A practical molecular assay to predict survival in resected non-squamous, non-small-cell lung cancer: development and international validation studies.
Lancet (London, England)
2012

The relative importance of predictors of body mass index change, overweight and obesity in adolescent girls.
International journal of pediatric obesity : IJPO : an official journal of the International Association for the Study of Obesity
2011

Sequence-based classification using discriminatory motif feature selection.
PloS one
2011

Screening prevalence and incidence of colorectal cancer among American Indian/Alaskan natives in the Indian Health Service.
Digestive diseases and sciences
2011

Relaxin induces rapid dilation of rodent small renal and human subcutaneous arteries via PI3 kinase and nitric oxide.
Endocrinology
2011

Frequent coexistence of anti-topoisomerase I and anti-U1RNP autoantibodies in African American patients associated with mild skin involvement: a retrospective clinical study.
Arthritis research & therapy
2011

Downregulation of EMX2 is associated with clinical outcomes in lung adenocarcinoma patients.
Clinical lung cancer
2011

A Novel Circulating Cxcr5-Cd20++ B Cell Compartment in Patients With Systemic Lupus Erythematosus
Arthritis and Rheumatism
2011

Uric acid and hypertension: cause or effect?
Current rheumatology reports
2010

Monocyte surface expression of Fcgamma receptor RI (CD64), a biomarker reflecting type-I interferon levels in systemic lupus erythematosus.
Arthritis research & therapy
2010

Lactobacillus casei abundance is associated with profound shifts in the infant gut microbiome.
PloS one
2010

Induction of nitric oxide by erythropoietin is mediated by the {beta} common receptor and requires interaction with VEGF receptor 2.
Blood
2010

Endothelial progenitor cells and endothelial vesicles - what is the significance for patients with chronic kidney disease?
Blood purification
2010

Endogenous type-I interferon activity is not associated with depression or fatigue in systemic lupus erythematosus.
Journal of neuroimmunology
2010

Cryoglobulinemic Mpgn in a Patient With Scleroderma and Sjogren's Syndrome

2010

Urinary CD80 excretion increases in idiopathic minimal-change disease.
Journal of the American Society of Nephrology : JASN
2009

The Erythropoietin Heterodimeric Beta Common Receptor Is in a Complex With and Requires Vegfr2 for Downstream Signaling
Circulation
2009

Simultaneous determination of uric acid metabolites allantoin, 6-aminouracil, and triuret in human urine using liquid chromatography-mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
2009

Role of relaxin in maternal systemic and renal vascular adaptations during gestation.
Annals of the New York Academy of Sciences
2009

Mechanisms of Relaxin-Induced Rapid Arterial Relaxation.
Reproductive Sciences
2009

Lowering blood pressure blocks mesangiolysis and mesangial nodules, but not tubulointerstitial injury, in diabetic eNOS knockout mice.
The American journal of pathology
2009

Long-term risk of mortality and acute kidney injury during hospitalization after major surgery.
Annals of surgery
2009

Lambda chops: creation of site-directed mutants in insertable fragments utilizing Gateway technology.
Molecular biotechnology
2009

Increased expression of FcgammaRI/CD64 on circulating monocytes parallels ongoing inflammation and nephritis in lupus.
Arthritis research & therapy
2009

Identification of yeast transcriptional regulation networks using multivariate random forests.
PLoS computational biology
2009

Hypothesis: could excessive fructose intake and uric acid cause type 2 diabetes?
Endocrine reviews
2009

Diabetic retinopathy is associated with bone marrow neuropathy and a depressed peripheral clock.
The Journal of experimental medicine
2009

Citrulline dependence of anti-cyclic citrullinated peptide antibodies in systemic lupus erythematosus as a marker of deforming/erosive arthritis.
The Journal of rheumatology
2009

Altered Homeostasis of Cd4+Memory T Cells in Peripheral Blood of Active Lupus Patients
Journal of Allergy and Clinical Immunology
2009

Acute kidney injury is associated with increased long-term mortality after cardiothoracic surgery.
Circulation
2009

Tacrolimus rescue therapy in resistant or relapsing cases of primary glomerulonephritis.
Journal of nephrology
2008

Simple, defensible sample sizes based on cost efficiency.
Biometrics
2008

No Unique Role for Fructose Sweeteners in Obesity Or Cardiorenal Disease - Reply
American Journal of Clinical Nutrition
2008

Long-term engraftment of bone marrow-derived cells in the intimal hyperplasia lesion of autologous vein grafts.
The American journal of pathology
2008

How safe is fructose for persons with or without diabetes?
The American journal of clinical nutrition
2008

Carbon monoxide and nitric oxide mediate cytoskeletal reorganization in microvascular cells via vasodilator-stimulated phosphoprotein phosphorylation: evidence for blunted responsiveness in diabetes.
Diabetes
2008

Biological sequence classification utilizing positive and unlabeled data.
Bioinformatics (Oxford, England)
2008

Urinary analysis of 8-oxoguanine, 8-oxoguanosine, fapy-guanine and 8-oxo-2'-deoxyguanosine by high-performance liquid chromatography-electrospray tandem mass spectrometry as a measure of oxidative stress.
Journal of chromatography. A
2007

Type I interferon as a novel risk factor for endothelial progenitor cell depletion and endothelial dysfunction in systemic lupus erythematosus.
Arthritis and rheumatism
2007

The relationship between self-rated health and mortality in older black and white Americans.
Journal of the American Geriatrics Society
2007

Retinal and choroidal microangiopathies: therapeutic opportunities.
Microvascular research
2007

Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease.
The American journal of clinical nutrition
2007

Mitomycin- and calcineurin-associated HUS, endothelial dysfunction and endothelial repair: a new paradigm for the puzzle?
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
2007

Is the fructose index more relevant with regards to cardiovascular disease than the glycemic index?
European journal of nutrition
2007

Autoantibodies to RNA helicase A: a new serologic marker of early lupus.
Arthritis and rheumatism
2007

A multi-array multi-SNP genotyping algorithm for Affymetrix SNP microarrays.
Bioinformatics (Oxford, England)
2007

A breakthrough in diabetic nephropathy: the role of endothelial dysfunction.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
2007

Urinary biomarkers in lupus nephritis.
Autoimmunity reviews
2006

Unearthing uric acid: an ancient factor with recently found significance in renal and cardiovascular disease.
Kidney international
2006

Short-term atorvastatin treatment enhances specific antibody production following tetanus toxoid vaccination in healthy volunteers.
Vaccine
2006

Nitric oxide cytoskeletal-induced alterations reverse the endothelial progenitor cell migratory defect associated with diabetes.
Diabetes
2006

Greater CD4 T-cell gains after one year of antiretroviral therapy are associated with lower HIV-1 pol replication capacity.
AIDS (London, England)
2006

Endothelial health and diversity in the kidney.
Journal of the American Society of Nephrology : JASN
2006

Development and validation of a prognostic index for 4-year mortality in older adults.
JAMA
2006

Autoantibodies against the replication protein A complex in systemic lupus erythematosus and other autoimmune diseases.
Arthritis research & therapy
2006

A case of unfulfilled expectations. Cytokines in idiopathic minimal lesion nephrotic syndrome.
Pediatric nephrology (Berlin, Germany)
2006

Stepwise normalization of two-channel spotted microarrays.
Statistical applications in genetics and molecular biology
2005

SDF-1 is both necessary and sufficient to promote proliferative retinopathy.
The Journal of clinical investigation
2005

Identifying differentially expressed genes from microarray experiments via statistic synthesis.
Bioinformatics (Oxford, England)
2005

High sensitivity C-reactive protein in systemic lupus erythematosus: relation to disease activity, clinical presentation and implications for cardiovascular risk.
Lupus
2005

Ethics and sample size.
American journal of epidemiology
2005

Essential hypertension, progressive renal disease, and uric acid: a pathogenetic link?
Journal of the American Society of Nephrology : JASN
2005

DNA topoisomerase II in therapy-related acute promyelocytic leukemia.
The New England journal of medicine
2005

Circulating endothelial cells are associated with future vascular events in hemodialysis patients.
Kidney international
2005

Association of anti-nucleoprotein autoantibodies with upregulation of Type I interferon-inducible gene transcripts and dendritic cell maturation in systemic lupus erythematosus.
Clinical immunology (Orlando, Fla.)
2005

Analysis of a splice array experiment elucidates roles of chromatin elongation factor Spt4-5 in splicing.
PLoS computational biology
2005

A novel mouse model of autologous venous graft intimal hyperplasia.
The Journal of surgical research
2005

Vitreous levels of vascular endothelial growth factor and stromal-derived factor 1 in patients with diabetic retinopathy and cystoid macular edema before and after intraocular injection of triamcinolone.
Archives of ophthalmology (Chicago, Ill. : 1960)
2004

Thrombotic microangiopathy associated with unusual viral sequences in HIV-1-positive patients.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
2004

The 1.4-MDa apoptosome is a critical intermediate in apoptosome maturation.
American journal of physiology. Cell physiology
2004

Strong association of a functional polymorphism in the monocyte chemoattractant protein 1 promoter gene with lupus nephritis.
Arthritis and rheumatism
2004

Real-time analysis of apoptosis in vivo.
Methods in cell biology
2004

Higher CD4+ T cell counts associated with low viral pol replication capacity among treatment-naive adults in early HIV-1 infection.
The Journal of infectious diseases
2004

Diuretic-induced hyperuricemia does not decrease cardiovascular risk.
Journal of hypertension
2004

Intimal exuberance: veins in jeopardy.
The American journal of pathology
2003

Factors associated with future amputation among patients undergoing hemodialysis: results from the Dialysis Morbidity and Mortality Study Waves 3 and 4.
American journal of kidney diseases : the official journal of the National Kidney Foundation
2003

Circulating endothelial cells as potential markers of the state of the endothelium in hemodialysis patients.
American journal of kidney diseases : the official journal of the National Kidney Foundation
2003

Marker for real-time analysis of caspase activity in intact cells.
BioTechniques
2002

Circulating endothelial cells: tea leaves for renal disease.
American journal of physiology. Renal physiology
2002

Effect of pH, ionic charge, and osmolality on cytochrome c-mediated caspase-3 activity.
American journal of physiology. Cell physiology
2001

Kringle 5 causes cell cycle arrest and apoptosis of endothelial cells.
Biochemical and biophysical research communications
1999

Endostatin induces endothelial cell apoptosis.
The Journal of biological chemistry
1999

Association between lifetime ambient ozone exposure and pulmonary function in college freshmen--results of a pilot study.
Environmental research
1997

Development of neuronal precursor cells and functional postmitotic neurons from embryonic stem cells in vitro.
Mechanisms of development
1996

Serum beta 2-microglobulin and prediction of progression to AIDS in HIV infection.
Lancet (London, England)
1992

Living arrangements and survival among middle-aged and older adults in the NHANES I epidemiologic follow-up study.
American journal of public health
1992

Correlates of knee pain among US adults with and without radiographic knee osteoarthritis.
The Journal of rheumatology
1992

A comparison of black and white family caregivers experience with dementia.
Journal of National Black Nurses' Association : JNBNA
1991

The influence of oral potassium chloride on blood pressure in hypertensive men on a low-sodium diet.
The New England journal of medicine
1990

Body fat distribution, blood pressure, and hypertension. A prospective cohort study of men in the normative aging study.
Annals of epidemiology
1990

A "state model" of renal function in systemic lupus erythematosus: its value in the prediction of outcome in 292 patients.
The Journal of rheumatology
1989

Isoproterenol aerosols.
Annals of allergy
1975

The mechanics of breathing in different body positions. II. In cardiopulmonary disease.
The Journal of clinical investigation
1956

EVALUATION OF THERAPEUTIC SUBSTANCES EMPLOYED FOR THE RELIEF OF BRONCHOSPASM. VI. AMINOPHYLLINE.
The Journal of clinical investigation
1949

Research Interests

Dr. Segal's research focuses on the mechanisms of the increased cardiovascular disease in patients with diabetes, chronic kidney disease, systemic lupus erythematosus (SLE), and women who have preeclampsia or preterm delivery. His hypothesis is that a key determinate of whether an individual will develop chronic kidney disease or atherosclerosis is the ability of the individual's endothelium to tolerate their level of blood pressure, glycemia, or other stressors to the endothelium.