Eric Sobel, M.D.

Eric S Sobel, M.D., Ph.D.

(352) 265-4846

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Publications

Immunophenotyping reveals distinct subgroups of lupus patients based on their activated T cell subsets.
Clinical immunology (Orlando, Fla.)
2020

Autoimmune inner ear disease: A systematic review of management.
Laryngoscope investigative otolaryngology
2020

The utility of trough mycophenolic acid levels for the management of lupus nephritis.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
2019

Metformin Inhibits the Type 1 IFN Response in Human CD4+ T Cells.
Journal of immunology (Baltimore, Md. : 1950)
2019

A case of isolated renal involvement of polyarteritis nodosa successfully treated with steroid monotherapy.
BMJ case reports
2016

A Novel Mechanism for Generating the Interferon Signature in Lupus: Opsonization of Dead Cells by Complement and IgM.
Arthritis & rheumatology (Hoboken, N.J.)
2016

Serpin treatment suppresses inflammatory vascular lesions in temporal artery implants (TAI) from patients with giant cell arteritis.
PloS one
2015

Normalization of CD4+ T cell metabolism reverses lupus.
Science translational medicine
2015

The Combination of Metformin and 2-Deoxy-D-Glucose Normalizes Cd4 T Cell Metabolism and Functions, and Reverse Disease in Murine Models of Lupus.
Arthritis & Rheumatology
2014

Reduced levels of CCL2 and CXCL10 in systemic lupus erythematosus patients under treatment with prednisone, mycophenolate mofetil, or hydroxychloroquine, except in a high STAT1 subset.
Arthritis research & therapy
2014

Positive correlation of STAT1 and miR-146a with anemia in patients with systemic lupus erythematosus.
Journal of clinical immunology
2014

Osteoarthritis and psoriatic arthritis: findings in three-dimensional biophotonics imaging.
Bio-medical materials and engineering
2014

Increased IFN-α-producing plasmacytoid dendritic cells (pDCs) in human Th1-mediated type 1 diabetes: pDCs augment Th1 responses through IFN-α production.
Journal of immunology (Baltimore, Md. : 1950)
2014

Elevated signal transducers and activators of transcription 1 correlates with increased C-C motif chemokine ligand 2 and C-X-C motif chemokine 10 levels in peripheral blood of patients with systemic lupus erythematosus.
Arthritis research & therapy
2014

Noninvasive Imaging of Hemoglobin Concentration and Oxygen Saturation for Detection of Osteoarthritis in the Finger Joints Using Multispectral Three-Dimensional Quantitative Photoacoustic Tomography
Journal of Optics
2013

Maintenance of anti-Sm/RNP autoantibody production by plasma cells residing in ectopic lymphoid tissue and bone marrow memory B cells.
Journal of immunology (Baltimore, Md. : 1950)
2013

Cd40 Exon 8 Deficiency Causes a Novel Form of Immunodeficiency With Hyper-Igm
Journal of Immunology
2013

Anti-Th/To Antibodies in Various Systemic Rheumatic Diseases Screened By Anti-Rpp25 Elisa.
Arthritis and Rheumatism
2013

Pre-B cell leukemia homeobox 1 is associated with lupus susceptibility in mice and humans.
Journal of immunology (Baltimore, Md. : 1950)
2012

Gemin5 Is a New Target of Autoantibodies That Are Produced in Tight Connection With Antibodies To Snrnps and Survival of Motor Neuron (Smn) Complex
Arthritis and Rheumatism
2012

Effects of Treatment On the Expression of Ccl2 and Cxcl10 in Systemic Lupus Erythematosus Patients
Arthritis and Rheumatism
2012

Correlation of Signal Transducers and Activators of Transcription-1 and Microrna-146a With Anaemia and Other Clinical Features in Systemic Lupus Erythematosus Patients
Arthritis and Rheumatism
2012

Coexistence of anti-RNA polymerase III and anti-U1RNP antibodies in patients with systemic lupus erythematosus: two cases without features of scleroderma.
Lupus
2012

Clinical Features Associated With Anti-Th/To in Non-Scleroderma Patients - Sine Scleroderma?
Arthritis and Rheumatism
2012

Clinical Features Associated With Anti-Th/To in Non-Scleroderma Patients - Sine Scleroderma?
Arthritis and Rheumatism
2012

Autoantibodies to transcription intermediary factor TIF1β associated with dermatomyositis.
Arthritis research & therapy
2012

Autoantibodies To Survival of Motor Neuron (Smn) Complex Are Common in Patients With Anti-U1Rnp/Sm and Are Associated With Features of Scleroderma and Myopathy.
Arthritis and Rheumatism
2012

A New Linked Set of Autoantibodies in Dermatomyositis: Anti-Mi-2 and Anti-Transcription Intermediary Factor (Tif) 1Alpha.
Arthritis and Rheumatism
2012

Viral serpin therapeutics from concept to clinic.
Methods in enzymology
2011

Transcription Intermediary Factor (Tif)-1 Beta Is a New Dermatomyositis Autoantigen
Arthritis and Rheumatism
2011

Pathogenic role of B cells in the development of diffuse alveolar hemorrhage induced by pristane.
Laboratory investigation; a journal of technical methods and pathology
2011

IL-1α modulates neutrophil recruitment in chronic inflammation induced by hydrocarbon oil.
Journal of immunology (Baltimore, Md. : 1950)
2011

Gender and ethnicity differences in the prevalence of scleroderma-related autoantibodies.
Clinical rheumatology
2011

Frequent coexistence of anti-topoisomerase I and anti-U1RNP autoantibodies in African American patients associated with mild skin involvement: a retrospective clinical study.
Arthritis research & therapy
2011

First assessment of three-dimensional quantitative photoacoustic tomography for in vivo detection of osteoarthritis in the finger joints.
Medical physics
2011

Distinctive Pattern of Myositis-Specific Autoantibody Production Between American Caucasian and Italian Patients With Polymyositis/Dermatomyositis
Arthritis and Rheumatism
2011

Defective response of CD4(+) T cells to retinoic acid and TGFβ in systemic lupus erythematosus.
Arthritis research & therapy
2011

Computer-aided classification of optical images for diagnosis of osteoarthritis in the finger joints.
Journal of X-ray science and technology
2011

Autoantibodies to survival of motor neuron complex in patients with polymyositis: immunoprecipitation of D, E, F, and G proteins without other components of small nuclear ribonucleoproteins.
Arthritis and rheumatism
2011

Atypical clinical presentation of a subset of patients with anti-RNA polymerase III--non-scleroderma cases associated with dominant RNA polymerase I reactivity and nucleolar staining.
Arthritis research & therapy
2011

A Novel Circulating Cxcr5-Cd20++ B Cell Compartment in Patients With Systemic Lupus Erythematosus
Arthritis and Rheumatism
2011

Quantitative two-dimensional photoacoustic tomography of osteoarthritis in the finger joints.
Optics express
2010

Murine lupus susceptibility locus Sle1a requires the expression of two sub-loci to induce inflammatory T cells.
Genes and immunity
2010

Monocyte surface expression of Fcgamma receptor RI (CD64), a biomarker reflecting type-I interferon levels in systemic lupus erythematosus.
Arthritis research & therapy
2010

Image-guided optical spectroscopy in diagnosis of osteoarthritis: a clinical study.
Biomedical optics express
2010

High-resolution x-ray guided three-dimensional diffuse optical tomography of joint tissues in hand osteoarthritis: morphological and functional assessments.
Medical physics
2010

Endogenous type-I interferon activity is not associated with depression or fatigue in systemic lupus erythematosus.
Journal of neuroimmunology
2010

Type I interferon modulates monocyte recruitment and maturation in chronic inflammation.
The American journal of pathology
2009

Quantitative three-dimensional photoacoustic tomography of the finger joints: an in vivo study.
Journal of biomedical optics
2009

Increased expression of FcgammaRI/CD64 on circulating monocytes parallels ongoing inflammation and nephritis in lupus.
Arthritis research & therapy
2009

Defective Retinoic Acid Expansion of Foxp3+Regulatory T Cells in Lupus
Clinical Immunology
2009

Comparison of diffusion approximation and higher order diffusion equations for optical tomography of osteoarthritis.
Journal of biomedical optics
2009

Citrulline dependence of anti-cyclic citrullinated peptide antibodies in systemic lupus erythematosus as a marker of deforming/erosive arthritis.
The Journal of rheumatology
2009

Altered Homeostasis of Cd4+Memory T Cells in Peripheral Blood of Active Lupus Patients
Journal of Allergy and Clinical Immunology
2009

Tomographic x-ray-guided three-dimensional diffuse optical tomography of osteoarthritis in the finger joints.
Journal of biomedical optics
2008

Significant Racial and Gender Differences in Specificity of Scleroderma-Related Autoantibodies
Arthritis and Rheumatism
2008

Patients with pulmonary tuberculosis are frequently positive for anti-cyclic citrullinated peptide antibodies, but their sera also react with unmodified arginine-containing peptide.
Arthritis and rheumatism
2008

Intrafollicular location of marginal zone/CD1d(hi) B cells is associated with autoimmune pathology in a mouse model of lupus.
Laboratory investigation; a journal of technical methods and pathology
2008

High Affinity Fc Gamma Receptor Ri (Cd64), a Potential Biomarker To Monitor Type-I-Ifn Levels and Disease Activity in Sle
Arthritis and Rheumatism
2008

Defective B-cell response to T-dependent immunization in lupus-prone mice.
European journal of immunology
2008

Comparison of chlordecone and estradiol effects on splenic T-cells in (NZBxNZW)F(1) mice.
Toxicology letters
2008

Colocalization of antigen-specific B and T cells within ectopic lymphoid tissue following immunization with exogenous antigen.
Journal of immunology (Baltimore, Md. : 1950)
2008

Clinical Significance of Autoantibodies To Topoisomerase I and Rna Polymerase Iii in An Unselected Rheumatic Disease Population
Arthritis and Rheumatism
2008

Type I interferon as a novel risk factor for endothelial progenitor cell depletion and endothelial dysfunction in systemic lupus erythematosus.
Arthritis and rheumatism
2007

Three-dimensional diffuse optical tomography of osteoarthritis: initial results in the finger joints.
Journal of biomedical optics
2007

Murine lupus susceptibility locus Sle1a controls regulatory T cell number and function through multiple mechanisms.
Journal of immunology (Baltimore, Md. : 1950)
2007

Diminished prolactin from chlordecone treatment in ovariectomized (NZBxNZW)F(1) mice.
International immunopharmacology
2007

Deficiency of the type I interferon receptor protects mice from experimental lupus.
Arthritis and rheumatism
2007

Clinical implication of autoantibodies in patients with systemic rheumatic diseases.
Expert review of clinical immunology
2007

Autoantibodies to RNA helicase A: a new serologic marker of early lupus.
Arthritis and rheumatism
2007

Acceleration of autoimmunity by organochlorine pesticides: a comparison of splenic B-cell effects of chlordecone and estradiol in (NZBxNZW)F1 mice.
Toxicological sciences : an official journal of the Society of Toxicology
2007

Urinary biomarkers in lupus nephritis.
Autoimmunity reviews
2006

Type I interferon production by tertiary lymphoid tissue developing in response to 2,6,10,14-tetramethyl-pentadecane (pristane).
The American journal of pathology
2006

Lupus-like disease and high interferon levels corresponding to trisomy of the type I interferon cluster on chromosome 9p.
Arthritis and rheumatism
2006

Comparison of chlordecone effects on autoimmunity in (NZBxNZW) F(1) and BALB/c mice.
Toxicology
2006

T cell hyperactivity in lupus as a consequence of hyperstimulatory antigen-presenting cells.
The Journal of clinical investigation
2005

Several genes contribute to the production of autoreactive B and T cells in the murine lupus susceptibility locus Sle1c.
Journal of immunology (Baltimore, Md. : 1950)
2005

Induction of apoptosis by the hydrocarbon oil pristane: implications for pristane-induced lupus.
Journal of immunology (Baltimore, Md. : 1950)
2005

High sensitivity C-reactive protein in systemic lupus erythematosus: relation to disease activity, clinical presentation and implications for cardiovascular risk.
Lupus
2005

Genetic dissection of systemic lupus erythematosus pathogenesis: partial functional complementation between Sle1 and Sle3/5 demonstrates requirement for intracellular coexpression for full phenotypic expression of lupus.
Journal of immunology (Baltimore, Md. : 1950)
2005

Association of anti-nucleoprotein autoantibodies with upregulation of Type I interferon-inducible gene transcripts and dendritic cell maturation in systemic lupus erythematosus.
Clinical immunology (Orlando, Fla.)
2005

Acceleration of autoimmunity by organochlorine pesticides in (NZB x NZW)F1 mice.
Environmental health perspectives
2005

Strong association of a functional polymorphism in the monocyte chemoattractant protein 1 promoter gene with lupus nephritis.
Arthritis and rheumatism
2004

Mechanisms of peritoneal B-1a cells accumulation induced by murine lupus susceptibility locus Sle2.
Journal of immunology (Baltimore, Md. : 1950)
2004

Genetic dissection of lupus pathogenesis: Sle3/5 impacts IgH CDR3 sequences, somatic mutations, and receptor editing.
Journal of immunology (Baltimore, Md. : 1950)
2004

Diagnostic accuracy for lupus and other systemic autoimmune diseases in the community setting.
Archives of internal medicine
2004

Systemic overexpression of IL-10 induces CD4+CD25+ cell populations in vivo and ameliorates type 1 diabetes in nonobese diabetic mice in a dose-dependent fashion.
Journal of immunology (Baltimore, Md. : 1950)
2003

The major murine systemic lupus erythematosus susceptibility locus Sle1 results in abnormal functions of both B and T cells.
Journal of immunology (Baltimore, Md. : 1950)
2002

Genetic dissection of systemic lupus erythematosus pathogenesis: evidence for functional expression of Sle3/5 by non-T cells.
Journal of immunology (Baltimore, Md. : 1950)
2002

Genetic dissection of SLE pathogenesis: adoptive transfer of Sle1 mediates the loss of tolerance by bone marrow-derived B cells.
Journal of immunology (Baltimore, Md. : 1950)
1999

Aberrant expression of the NF-kappaB and IkappaB proteins in B cells from viable motheaten mice.
Autoimmunity
1999

Use of phosphorothioate-modified oligodeoxynucleotides to inhibit NF-kappaB expression and lymphocyte function.
Clinical immunology and immunopathology
1998

Resistance to HgCl2-induced autoimmunity in haplotype-heterozygous mice is an intrinsic property of B cells.
Journal of immunology (Baltimore, Md. : 1950)
1998

Prevention of experimental allergic encephalomyelitis by an antibody to CD45RB.
Cellular immunology
1998

Novel immunoregulatory B cell pathways revealed by lpr-+ mixed chimeras.
Journal of immunology (Baltimore, Md. : 1950)
1998

Functional consequences of the SHP-1 defect in motheaten viable mice: role of NF-kappa B.
Cellular immunology
1998

Inhibition of the p50 (NKkappaB1) subunit of NF-kappaB by phosphorothioate-modified antisense oligodeoxynucleotides reduces NF-kappaB expression and immunoglobulin synthesis in murine B cells.
Clinical immunology and immunopathology
1997

Class II haplotype differentially regulates immune response in HgCl2-treated mice.
Clinical immunology and immunopathology
1997

B cell genotype determines the fine specificity of autoantibody in lpr mice.
Journal of immunology (Baltimore, Md. : 1950)
1997

Phenotypic abnormalities of splenic and bone marrow B cells in lpr and gld mice.
Clinical immunology and immunopathology
1996

Hyperproliferation of BXSB B cells is linked to the Yaa allele.
Clinical immunology and immunopathology
1996

Cellular interactions in the lpr and gld models of systemic autoimmunity.
Advances in dental research
1996

The abnormal lpr double-negative T cell fails to proliferate in vivo.
Clinical immunology and immunopathology
1995

The Yaa gene-mediated acceleration of murine lupus: Yaa- T cells from non-autoimmune mice collaborate with Yaa+ B cells to produce lupus autoantibodies in vivo.
European journal of immunology
1995

In vivo depletion of Thy-1-positive cells originating from normal bone marrow abrogates the suppression of gld disease in normal-gld mixed bone marrow chimeras.
Journal of immunology (Baltimore, Md. : 1950)
1995

Co-infusion of normal bone marrow partially corrects the gld T-cell defect. Evidence for an intrinsic and extrinsic role for Fas ligand.
Journal of immunology (Baltimore, Md. : 1950)
1995

The role of B cell abnormalities in the systemic autoimmune syndromes of lpr and gld mice.
Seminars in immunology
1994

T-B collaboration for autoantibody production in lpr mice is cognate and MHC-restricted.
Journal of immunology (Baltimore, Md. : 1950)
1994

lpr T cells are necessary for autoantibody production in lpr mice.
Journal of immunology (Baltimore, Md. : 1950)
1993

Correction of gld autoimmunity by co-infusion of normal bone marrow suggests that gld is a mutation of the Fas ligand gene.
International immunology
1993

Conventional B cells, not B1 cells, are the source of autoantibodies in chronic graft-versus-host disease.
Journal of immunology (Baltimore, Md. : 1950)
1993

Conventional B cells, not B-1 cells, are responsible for producing autoantibodies in lpr mice.
The Journal of experimental medicine
1993

Antigen nonspecific effect of major histocompatibility complex haplotype on autoantibody levels in systemic lupus erythematosus-prone lpr mice.
The Journal of clinical investigation
1993

Aberrant expression of the very early activation antigen on MRL/Mp-lpr/lpr lymphocytes.
Journal of immunology (Baltimore, Md. : 1950)
1993

The role of CD5+ B cells in the production of autoantibodies in murine systemic lupus erythematosus.
Annals of the New York Academy of Sciences
1992

An intrinsic B cell defect is required for the production of autoantibodies in the lpr model of murine systemic autoimmunity.
The Journal of experimental medicine
1991

Research Interests

Our laboratory is interested in murine models of autoimmune disease, both spontaneous and induced. We have two major projects. The first uses mercury chloride to induce an anti-nucleolar response in certain strains of mice. This response is directed to fibrillarin, a ribosomal RNA processing protein and is a specificity most commonly found in systemic sclerosis (scleroderma). We are examining the cellular interactions leading to this response.

In the second major project, we are collaborating with Dr. Edward Wakeland and Dr. Laurence Morel in the complex genetic inheritance of lupus in the NZM/2410 mice, which were derived from the classic (NZBxNZW)F1 model. Genetic intervals have been identified and individually backcrossed onto non-autoimmune strains of mice. Through bone marrow transplant experiments, we are exploring how these genes are expressed and delineating the immunological pathways they affect. The overall goal is to identify genes leading to a break in tolerance to self-antigen.